ea0081p125 | Endocrine-Related Cancer | ECE2022
Williams Jack
, Smith Chris
, Hall Charlotte
, Khaled Zakaa
, Maharaj Avinaash
, Kwong Ruth
, Pittaway James
, Casas Josefina
, Parvanta Laila
, Abdel-Aziz Tarek
, Palazzo Fausto
, Chung Teng-Teng
, Guasti Leonardo
, Metherell Louise
, Prasad Rathi
Introduction: Sphingosine-1-phosphate lyase (SGPL1) catalyses the final step in sphingolipid metabolism, irreversibly degrading the lipid signalling molecule sphingosine-1-phosphate (S1P). The relative abundance of S1P compared to its precursors sphingosine and ceramide finely tunes signal transduction for a wide range of cellular pathways including proliferation, apoptosis, migration and calcium handling. Loss-of-function mutations in SGPL1 cause a spectrum of disorders, incl...